Zhalko-Titarenko V P, Bondarenko V M, Grigor'ev A V, Kupchinskiĭ L G, Rybalko S L
Zh Mikrobiol Epidemiol Immunobiol. 1986 Apr(4):21-4.
The study of the adhesion of Shigella flexneri to intestinal mucosal explants from human postabortion fetuses, used as an experimental model, has revealed that the process of interaction between the infective agent and the epithelium develops in accordance with Langmuir's equation of the adsorption isotherm. The specific biological feature of the adhesive interaction between bacteria and the mucous membrane is the fact that the effective adhesion of microbes is possible only in case of their high concentration on the surface of the mucous membrane. In case of their low concentration in the parietal layer no microbial adhesion is observed, whereas epithelial villi infected with shigellae and fixed to the mucous membrane of the explant produce a high parietal concentration of the infective agents, which leads to the increase of adhesion by more than two orders.
以人流产胎儿的肠黏膜外植体作为实验模型，对福氏志贺菌与该模型的黏附研究表明，感染因子与上皮细胞之间的相互作用过程符合朗缪尔吸附等温线方程。细菌与黏膜之间黏附相互作用的特定生物学特征是，只有当微生物在黏膜表面高度浓缩时，它们才可能有效黏附。如果它们在壁层中的浓度较低，则未观察到微生物黏附，而感染志贺菌并固定在外植体黏膜上的上皮绒毛会使感染因子在壁层中高度浓缩，这导致黏附增加超过两个数量级。
