Schmalstieg F C, Nelson J A, Mills G C, Monahan T M, Goldman A S, Goldblum R M
J Pediatr. 1977 Jul;91(1):48-51. doi: 10.1016/s0022-3476(77)80442-3.
It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which were deficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.
研究发现，在缺乏腺苷脱氨酶（ADA）的人血淋巴细胞中，三磷酸腺苷（ATP）和环磷酸腺苷（cAMP）大幅增加。某些其他嘌呤和嘧啶核苷酸也有所升高，但程度较轻。由于ATP与二磷酸腺苷（ADP）的比率显著低于正常水平，这些细胞中的能量产生可能受到核苷酸增加的抑制。因此，人类ADA缺乏症中的免疫缺陷似乎与淋巴细胞中核苷酸浓度的增加有关。
