Zhou Chao, Yu Guoqiang, Furuya Daisuke, Greenberg Joel, Yodh Arjun, Durduran Turgut
Opt Express. 2006 Feb 6;14(3):1125-44. doi: 10.1364/oe.14.001125.
Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues(~4mm) deep below the cortex.
扩散光学相关方法被应用于小动物模型中脑血流（CBF）的三维（3D）断层成像。使用扩散相关断层成像的噪声模型对图像重建进行了优化，这使得能够更好地进行数据选择和正则化。通过模拟数据以及在大鼠脑内活体皮层扩散性抑制（CSD）过程中展示了这种断层成像方法。通过完整颅骨获得了皮层下约4毫米深处组织中脑血流的三维图像。
