Sun George, Muddana Srikant, Slaughter James C, Casey Sean, Hill Eric, Farrokhi Farnoosh, Garrett C Gaelyn, Vaezi Michael F
Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-5280, USA.
Laryngoscope. 2009 Aug;119(8):1639-43. doi: 10.1002/lary.20282.
OBJECTIVES/HYPOTHESIS: Laryngopharyngeal reflux (LPR) represents a challenging field. Therapeutic studies of proton pump inhibitors in LPR have shown mixed results. The Restech pH catheter (Respiratory Technology Corp., San Diego, CA) is a minimally invasive device for detection of oropharyngeal acid reflux. The aim of this study was to provide normative data using this device in both distal esophagus and oropharynx.
Prospective observational study.
Normal volunteers were recruited to undergo pH monitoring. A custom made longer catheter was used to assess distal esophageal pH. Oropharyngeal pH catheter was placed at the level of uvula. The distribution of % time was summarized using the 5th, 25th, 50th (median), 75th, and 95th quantiles for pH < 6, pH < 5, and pH < 4 for both upright and supine positions.
A total of 20 normal, healthy volunteers underwent pH monitoring for 14 to 24 hours (median 20.5 hours). The 95th percentile for % total time pH < 4, pH < 5, pH < 6 for the distal esophageal pH catheter were 4.52%, 10.91%, and 42.99%, respectively. For the oropharynx pH probe, the 95th percentile for % total time pH < 4, pH < 5, and pH < 6 were 0.02%, 2.33%, and 21.41% respectively. The 95th percentile for number of reflux events for total pH < 4, pH < 5, and pH < 6 were 1.3, 8.1, and 128.0, respectively.
Oropharyngeal acid reflux is an infrequent occurrence in healthy volunteers without LPR. The normative data for Restech pH catheter may now be compared to those with suspected LPR.
目的/假设：喉咽反流（LPR）是一个具有挑战性的领域。质子泵抑制剂治疗LPR的研究结果不一。Restech pH导管（呼吸技术公司，加利福尼亚州圣地亚哥）是一种用于检测口咽酸反流的微创设备。本研究的目的是使用该设备提供远端食管和口咽的正常数据。
前瞻性观察研究。
招募正常志愿者进行pH监测。使用定制的更长导管评估远端食管pH。口咽pH导管放置在悬雍垂水平。采用第5、25、50（中位数）、75和95百分位数总结直立位和仰卧位时pH<6、pH<5和pH<4的时间百分比分布。
共有20名正常健康志愿者接受了14至24小时（中位数20.5小时）的pH监测。远端食管pH导管pH<4、pH<5、pH<6的总时间百分比的第95百分位数分别为4.52%、10.91%和42.99%。对于口咽pH探头，pH<4、pH<5和pH<6的总时间百分比的第95百分位数分别为0.02%、2.33%和21.41%。pH<4、pH<5和pH<6的反流事件总数的第95百分位数分别为1.3、8.1和128.0。
在无LPR的健康志愿者中，口咽酸反流很少见。现在可以将Restech pH导管的正常数据与疑似LPR患者的数据进行比较。
