Knight-Perry Jessica E, Field Joshua J, Debaun Michael R, Stocks Janet, Kirkby Jane, Strunk Robert C
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Pediatr Pulmonol. 2009 Jul;44(7):728-30. doi: 10.1002/ppul.21049.
Asthma is associated with increases in sickle cell disease (SCD)-related morbidity and mortality. A thorough evaluation for asthma in children with SCD is important and may involve methacholine challenge (MCh). In this report, we present a 14-year-old male with SCD who was admitted for an acute painful episode following MCh. Pain events after MCh have not been previously reported in children with SCD. The risk-benefit ratio should be strongly considered prior to performance of MCh in this patient population, and all possible complications, including an acute painful episode, should be openly discussed with the parents and pediatric patient.
哮喘与镰状细胞病(SCD)相关的发病率和死亡率增加有关。对患有SCD的儿童进行全面的哮喘评估很重要,可能需要进行乙酰甲胆碱激发试验(MCh)。在本报告中,我们介绍了一名14岁患有SCD的男性,他在MCh后因急性疼痛发作入院。此前尚未有关于患有SCD的儿童在MCh后发生疼痛事件的报道。在对该患者群体进行MCh之前,应充分考虑风险效益比,并且应与父母和儿科患者坦诚讨论所有可能的并发症,包括急性疼痛发作。