Mecocci P, Parnetti L, Reboldi G P, Santucci C, Gaiti A, Ferri C, Gernini I, Romagnoli M, Cadini D, Senin U
Institute of Gerontology, Perugia University, General Hospital, Italy.
Acta Neurol Scand. 1991 Sep;84(3):210-3. doi: 10.1111/j.1600-0404.1991.tb04940.x.
Albumin and IgG were determined in serum and cerebrospinal fluid (CSF) of patients with early-onset Alzheimer's disease (AD, n. 13), senile dementia of Alzheimer type (SDAT, n. 33), vascular dementia divided into multi-infarct (MID, n. 9) and probable vascular (PVD, n. 11) dementia. Albumin and IgG ratio and IgG index were calculated. CSF albumin and albumin ratio were significantly higher in MID patients indicating an increased BBB permeability. IgG ratio and IgG index did not show any significant difference among groups. These results do not provide evidence for BBB damage in AD/SDAT, while in MID the increase of CSF albumin and albumin ratio is suggestive of BBB dysfunction.
对早发性阿尔茨海默病（AD，13例）、阿尔茨海默型老年痴呆症（SDAT，33例）、分为多发性梗死性痴呆（MID，9例）和可能的血管性痴呆（PVD，11例）的血管性痴呆患者的血清和脑脊液（CSF）中的白蛋白和免疫球蛋白G（IgG）进行了测定。计算了白蛋白与IgG的比值以及IgG指数。MID患者的脑脊液白蛋白和白蛋白比值显著更高，表明血脑屏障（BBB）通透性增加。IgG比值和IgG指数在各组之间未显示出任何显著差异。这些结果并未为AD/SDAT中的血脑屏障损伤提供证据，而在MID中，脑脊液白蛋白和白蛋白比值的增加提示血脑屏障功能障碍。
