Jensen L N, Stürup J, Kramhøft M, Jensen J S
Department of Orthopaedics U, Rigshospitalet University of Copenhagen, Denmark.
Acta Orthop Belg. 1991;57(3):254-9.
This study was designed to investigate histological changes in the tibia of adult mongrel dogs receiving PMMA bone cement in one tibial shaft and an inert filler, Bone wax, in the other. Sixteen dogs were used, 2 dogs were investigated at one week, 6 dogs at four weeks and 8 dogs at twelve weeks. It was shown in this study, that intramedullary implantation of PMMA bone cement leads to considerable impairment of bone remodelling. At each period of observation the index periosteal apposition/cortex thickness was lower on the cemented side; at 4 weeks an index of 0.42 (0.17-0.64) compared to 0.72 (0.42-0.91), and a 60-70 microns concentric fibrillar fibrous membrane was seen between cement and bone. On the Bone wax side few or no areas of fibrous tissue were detected at both 4 and 12 weeks; and when such tissue was present, islands of bone developing directly onto the wax was seen. The bone remodelling was impaired on the cemented side and limited to the outer half after 4 weeks.
本研究旨在调查成年杂种犬一侧胫骨干植入聚甲基丙烯酸甲酯（PMMA）骨水泥，另一侧植入惰性填充物骨蜡后胫骨的组织学变化。共使用了16只犬，1周时观察2只，4周时观察6只，12周时观察8只。本研究表明，髓内植入PMMA骨水泥会导致骨重塑受到显著损害。在每个观察期，骨水泥侧的骨膜附着/皮质厚度指数均较低；4周时，该指数为0.42（0.17 - 0.64），而另一侧为0.72（0.42 - 0.91），并且在骨水泥与骨之间可见一层60 - 70微米的同心纤维状纤维膜。在骨蜡侧，4周和12周时均未检测到或仅检测到少量纤维组织区域；当存在此类组织时，可见直接在骨蜡上形成的骨岛。骨水泥侧的骨重塑受到损害，4周后仅限于外侧一半。
