Kramhøft M, Bødtker S, Nimb L, Jensen J S
Department of Orthopedic Surgery, Rigshospitalet, University of Copenhagen, Denmark.
J Arthroplasty. 1993 Oct;8(5):555-60.
In order to evaluate the mineralization of bone after polymethyl methacrylate cementation, measurements of the periosteal apposition were made histologically and measurements of the bone-mineral content were made by dual-photon absorptiometry of the tibial diaphysis in 15 adult mongrel dogs in paired studies. Six dogs were investigated 4 weeks after intramedullary reaming of both sides and obturation of the medullary cavity with bone-wax on one side. Nine dogs were reamed on both sides. The medullary cavities were filled with polymethyl methacrylate bone-cement and bone-wax, respectively. The authors found (1) an increased bone-mineral content and an increased periosteal apposition after filling with bone-wax in comparison with the reamed side and (2) a decreased bone-mineral content and a decreased periosteal apposition on the cemented side in comparison with bone-wax. These findings are interpreted as consequential upon repair processes with a high remodeling and mineralization rate after reaming or filling with bone-wax, whereas remodeling in inhibited after filling with acrylic bone-cement.
为了评估聚甲基丙烯酸甲酯骨水泥植入后骨的矿化情况，在一项配对研究中，对15只成年杂种犬的胫骨骨干进行组织学测量骨膜附着情况，并通过双能光子吸收法测量骨矿物质含量。6只犬在两侧髓腔扩髓后4周进行研究，一侧用骨蜡封闭髓腔。9只犬两侧均进行扩髓。髓腔分别用聚甲基丙烯酸甲酯骨水泥和骨蜡填充。作者发现：（1）与扩髓侧相比，用骨蜡填充后骨矿物质含量增加，骨膜附着增加；（2）与骨蜡填充侧相比，骨水泥植入侧骨矿物质含量降低，骨膜附着减少。这些发现被解释为扩髓或用骨蜡填充后具有高重塑和矿化率的修复过程的结果，而用丙烯酸骨水泥填充后重塑受到抑制。
