Nimb L, Stürup J, Jensen J S
Department of Orthopedics, Rigshospitalet, University of Copenhagen, Denmark.
J Biomed Mater Res. 1993 May;27(5):565-74. doi: 10.1002/jbm.820270503.
The histological response of bone to inert bone wax, conventional polymethylmethacrylate (PMMA), and a new formulation of bone cement, methylmethacrylate/n-decylmethacrylate/isobornylmethacrylate (MMA/DMA/IBMA) was investigated in canine tibial diaphysis. The new formulation of cement is characterized by a reduced exothermic temperature at curing and reduced leakage of chemicals to the adjacent bone. In comparison with bone wax, the MMA/DMA/IBMA bone cement did not differ significantly with respect to periosteal apposition and bone remodeling, although a tendency to inhibit the biological response was encountered. The MMA/DMA/IBMA was clearly superior to PMMA bone cement in respect to both bone necrosis and repair, as well as bone remodeling.
在犬胫骨骨干中研究了骨对惰性骨蜡、传统聚甲基丙烯酸甲酯（PMMA）以及一种新型骨水泥配方甲基丙烯酸甲酯/甲基丙烯酸正癸酯/甲基丙烯酸异冰片酯（MMA/DMA/IBMA）的组织学反应。这种新型骨水泥配方的特点是固化时放热温度降低，且化学物质向相邻骨的渗漏减少。与骨蜡相比，MMA/DMA/IBMA骨水泥在骨膜附着和骨重塑方面无显著差异，不过存在抑制生物学反应的趋势。在骨坏死与修复以及骨重塑方面，MMA/DMA/IBMA明显优于PMMA骨水泥。
