Stürup J, Nimb L, Jensen J S
Department of Orthopedics U, Rigshospitalet, University of Copenhagen, Denmark.
Acta Orthop Belg. 1992;58(4):388-94.
In canine studies the effect of intramedullary reaming on tubular bone was investigated in 4 dogs. Intramedullary reaming was further compared with reaming and intramedullary filling with bone wax in 6 dogs. Bone blood perfusion was measured by a microsphere technique and bone remodelling activity by 99mTc-MDP uptake. From histological sections bone necrosis and remodelling activity were estimated. The biological response increased with the surgical trauma. If the medullary cavity was only reamed, endosteal apposition was the predominant reaction. Obturation of the medullary cavity resulted in more vigorous subperiosteal and cortical reaction. It is concluded that the remodelling processes differ significantly between reamed bone and bone where the medullary cavity is reamed and blocked. Thus when testing bone cement the studies should include a control operation with obturation of the medullary canal in a way simulating bone cement.
在犬类研究中，对4只犬的管状骨进行了髓内扩髓效果的研究。在另外6只犬中，进一步比较了髓内扩髓与扩髓并髓内填充骨蜡的情况。采用微球技术测量骨血流灌注，通过99mTc-MDP摄取测量骨重塑活性。从组织学切片估计骨坏死和重塑活性。生物反应随手术创伤增加。如果仅进行髓腔扩髓，骨内膜贴附是主要反应。髓腔闭塞导致更强烈的骨膜下和皮质反应。得出的结论是，扩髓骨与髓腔扩髓并闭塞的骨之间的重塑过程有显著差异。因此，在测试骨水泥时，研究应包括以模拟骨水泥的方式进行髓腔闭塞的对照手术。
