一种通过恶唑并[3,2 - b]吲唑合成1H - 吲唑酮的路线。
An oxazolo[3,2-b]indazole route to 1H-indazolones.
作者信息
Oakdale James S, Solano Danielle M, Fettinger James C, Haddadin Makhluf J, Kurth Mark J
机构信息
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.
出版信息
Org Lett. 2009 Jul 2;11(13):2760-3. doi: 10.1021/ol900891s.
PMID:19505119
Abstract
The novel heterocycle 2,3-dihydrooxazolo[3,2-b]indazole has been synthesized and utilized to provide easy access to 1H-indazolones, particularly the previously unreported 2-(2-alkoxyethyl)-1H-indazol-3(2H)-ones. Mechanistic as well as optimization and reaction scope studies are reported.
摘要
新型杂环2,3-二氢恶唑并[3,2 - b]吲唑已被合成，并用于方便地制备1H-吲唑酮，特别是之前未报道的2-(2-烷氧基乙基)-1H-吲唑-3(2H)-酮。本文报道了其反应机理以及优化和反应范围的研究。
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