Brébion Gildas, David Anthony S, Jones Hugh M, Pilowsky Lyn S
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Cogn Behav Neurol. 2009 Jun;22(2):101-8. doi: 10.1097/WNN.0b013e3181a722a0.
The aim of this study was to investigate the verbal working memory deficit and decrease of motor and cognitive speed in patients with schizophrenia, and to clarify their associations with negative and depressive symptomatology.
Forty patients with schizophrenia and 41 healthy control individuals were administered the backward digit span to assess the working memory capacity, along with 3 tests of processing speed.
Patients demonstrated reduced backward digit span, as well as decreased motor and cognitive speed. Regression analyses indicated that the backward digit span was associated with cognitive speed. It was not associated with either negative or depressive symptoms. Decreased processing speed was unrelated to negative symptoms, but the depression score was significantly associated with the cognitive speed measure.
Working memory and processing speed seem to share a cognitive component. Depression, but not negative symptoms, affects processing speed, especially by decreasing cognitive speed.
本研究旨在调查精神分裂症患者的言语工作记忆缺陷以及运动和认知速度的下降情况，并阐明它们与阴性和抑郁症状的关联。
对40名精神分裂症患者和41名健康对照者进行了倒背数字广度测试以评估工作记忆容量，同时还进行了3项处理速度测试。
患者表现出倒背数字广度降低，以及运动和认知速度下降。回归分析表明，倒背数字广度与认知速度相关。它与阴性或抑郁症状均无关联。处理速度降低与阴性症状无关，但抑郁评分与认知速度测量值显著相关。
工作记忆和处理速度似乎共享一个认知成分。抑郁而非阴性症状会影响处理速度，尤其是通过降低认知速度来影响。
