Holthausen Esther A E, Wiersma Durk, Sitskoorn Margriet M, Dingemans Peter M, Schene Aart H, van den Bosch Robert J
Department of Psychiatry, University Hospital Groningen, Groningen, Netherlands.
Neuropsychology. 2003 Oct;17(4):539-47. doi: 10.1037/0894-4105.17.4.539.
Long-term memory impairment is often found in schizophrenia. The question remains whether this is caused by other cognitive deficits. One hundred eighteen first-episode patients were compared with 45 control participants on several memory tasks. The role of processing speed and central executive functions on memory performance was examined with regression analysis for all participants and for patients separately. Deficits were found in general verbal learning performance and retrieval in episodic memory and semantic memory. Processing speed reduced disease-related variance in all memory variables. Coordination, organization of information, and speed of processing were the best predictors for long-term memory deficits in patients. The amount of explained variance, however, is small, especially in general verbal learning performance.
长期记忆障碍在精神分裂症患者中经常被发现。问题在于这是否是由其他认知缺陷所导致的。将118名首发患者与45名对照参与者在多项记忆任务上进行了比较。通过对所有参与者以及单独对患者进行回归分析，研究了加工速度和中央执行功能对记忆表现的作用。在情景记忆和语义记忆的一般言语学习表现及提取方面发现了缺陷。加工速度降低了所有记忆变量中与疾病相关的差异。协调、信息组织和加工速度是患者长期记忆缺陷的最佳预测指标。然而，可解释的方差量很小，尤其是在一般言语学习表现方面。
