Lindner Jonathan R
Division of Cardiovascular Medicine, UHN-62, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Nat Rev Cardiol. 2009 Jul;6(7):475-81. doi: 10.1038/nrcardio.2009.77. Epub 2009 Jun 9.
Techniques for noninvasive imaging of specific disease-related molecular changes are being developed to enhance diagnosis and therapeutic decision making in the clinical setting, and to facilitate research efforts. Molecular imaging with contrast-enhanced ultrasonography relies on the detection of the acoustic signal produced by microbubble or nanoparticle agents that are targeted to sites of disease. This Review describes the basis for ultrasound molecular imaging, the unique features of contrast agent behavior or detector performance in relation to clinical or research needs, and the progress that has been made to date in imaging key events in cardiovascular medicine, such as atherosclerosis, postischemic inflammation, angiogenesis, transplant rejection and thrombus formation.
正在开发用于特定疾病相关分子变化的无创成像技术，以加强临床环境中的诊断和治疗决策，并促进研究工作。超声造影分子成像依赖于检测由靶向疾病部位的微泡或纳米颗粒剂产生的声学信号。本综述描述了超声分子成像的基础、与临床或研究需求相关的造影剂行为或探测器性能的独特特征，以及迄今为止在心血管医学关键事件成像方面取得的进展，如动脉粥样硬化、缺血后炎症、血管生成、移植排斥和血栓形成。
