Gołka Karolina Agnieszka, Kobierski Juliusz, Milczek Tomasz, Emerich Janusz
Katedra i Klinika Ginekologii i Ginekologii Onkologicznej Akademii Medycznej w Gdańsku.
Ginekol Pol. 2009 Apr;80(4):295-8.
"Hand-foot" syndrome is a well-documented, dermatologic reaction after several chemotherapeutic agents with wild spectrum of symptoms. To the best of our knowledge, palmar-plantar erythrodysesthesia syndrome--presented as irreversible cytotoxic side effect induced by gemcitabine alone--has not been reported so far. We present a case of a patient with a history of peripheral sensory neuropathy who developed a painless finger necrosis caused by gemcitabine used in the second-line therapy for progressive ovary cancer.
“手足”综合征是一种有充分文献记载的、在多种化疗药物治疗后出现的具有广泛症状谱的皮肤反应。据我们所知，单纯吉西他滨诱导产生的不可逆细胞毒性副作用——表现为掌跖红斑感觉异常综合征——目前尚未见报道。我们报告一例有周围感觉神经病变病史的患者，其在接受用于晚期卵巢癌二线治疗的吉西他滨治疗后出现无痛性手指坏死。
