Kamani J, Mani A U, Egwu G O, Kumshe H A
Parasitology Division, National Veterinary Research Institute, P.M.B. 01, Vom, Plateau State, Nigeria.
Ann Trop Med Parasitol. 2009 Jun;103(4):317-21. doi: 10.1179/136485909X435094.
The prevalence of antibodies (IgG) to Toxoplasma gondii among 180 adults from the Nigerian city of Maiduguri was determined as 23.9%, using a commercial ELISA. Although the men investigated were more likely to be seropositive than the women, the difference was not statistically significant (27.3% v. 19.8%; P>0.05). There was also no apparent association between educational level and seroprevalence. There was a positive correlation between the mean antibody titre and the age of the subjects, with seroprevalence highest among the subjects aged 51-60 years and lowest in the subjects aged<21 years. Worryingly, 10 (20%) of the 50 female subjects who were of child-bearing age (15-40 years) were among those found seropositive for anti-T. gondii IgG. The mean antibody titres of the seropositive subjects ranged between 16.5 IU/ml (the threshold for positivity being 16 IU/ml) and >1000 IU/ml. In addition to age, occupation and eating habits were also significantly associated with seropositivity. Compared with the subjects who had no pets, dog owners were twice as likely to be seropositive. The relative risks for cat and dog ownership were, however, only 0.79 and 0.69, respectively, indicating that these animals might not be the main sources of human infection with T. gondii in the study area.
采用商用酶联免疫吸附测定法（ELISA）对来自尼日利亚迈杜古里市的180名成年人进行检测，结果显示弓形虫抗体（IgG）的流行率为23.9%。尽管接受调查的男性血清阳性的可能性高于女性，但差异无统计学意义（27.3%对19.8%；P>0.05）。教育水平与血清阳性率之间也没有明显关联。平均抗体滴度与受试者年龄呈正相关，血清阳性率在51 - 60岁的受试者中最高，在年龄小于21岁的受试者中最低。令人担忧的是，在50名育龄期（15 - 40岁）女性受试者中，有10名（20%）弓形虫抗IgG检测呈血清阳性。血清阳性受试者的平均抗体滴度在16.5 IU/ml（阳性阈值为16 IU/ml）至>1000 IU/ml之间。除年龄外，职业和饮食习惯也与血清阳性显著相关。与没有宠物的受试者相比，养狗者血清阳性的可能性是其两倍。然而，养猫和养狗的相对风险分别仅为0.79和0.69，这表明在研究区域这些动物可能不是人类感染弓形虫的主要来源。
