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从长远来看,精神病的早期干预是否具有成本效益?

Is early intervention in psychosis cost-effective over the long term?

作者信息

Mihalopoulos Cathrine, Harris Meredith, Henry Lisa, Harrigan Susy, McGorry Patrick

机构信息

Deakin Health Economics, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.

出版信息

Schizophr Bull. 2009 Sep;35(5):909-18. doi: 10.1093/schbul/sbp054. Epub 2009 Jun 9.

Abstract

OBJECTIVE

This study assesses the long-term cost-effectiveness of a comprehensive model of mental health care for first-episode psychosis. The study is an extension of a previous economic evaluation of the Early Psychosis Prevention and Intervention Centre (EPPIC) that assessed the first-year costs and outcomes of treatment.

METHOD

The current study used a matched, historical control group design with a follow-up of approximately 8 years. Complete follow-up data were available for 65 of the original 102 participants. Direct public mental health service costs incurred subsequent to the first year of treatment and symptomatic and functional outcomes of 32 participants initially treated for up to 2 years at EPPIC were compared with a matched cohort of 33 participants initially treated by generic mental health services. Treatment-related resource use was measured and valued using Australian published prices.

RESULTS

Almost 8 years after initial treatment, EPPIC subjects displayed lower levels of positive psychotic symptoms (P = .007), were more likely to be in remission (P = .008), and had a more favorable course of illness (P = .011) than the controls. Fifty-six percent of the EPPIC cohort were in paid employment over the last 2 years compared with 33% of controls (P = .083). Each EPPIC patient costs on average A$3445 per annum to treat compared with controls, who each costs A$9503 per annum.

CONCLUSIONS

Specialized early psychosis programs can deliver a higher recovery rate at one-third the cost of standard public mental health services. Residual methodological limitations and limited sample size indicate that further research is required to verify this finding.

摘要

目的

本研究评估了针对首发精神病的综合精神卫生保健模式的长期成本效益。该研究是早期精神病预防与干预中心(EPPIC)先前经济评估的扩展,先前的评估评估了治疗的第一年成本和结果。

方法

本研究采用匹配的历史对照组设计,随访约8年。102名原始参与者中有65名可获得完整的随访数据。将EPPIC最初治疗长达2年的32名参与者在治疗第一年之后产生的直接公共精神卫生服务成本以及症状和功能结果与33名最初由普通精神卫生服务治疗的匹配队列进行比较。使用澳大利亚公布的价格对与治疗相关的资源使用进行测量和估值。

结果

初始治疗近8年后,与对照组相比,EPPIC受试者的阳性精神病症状水平较低(P = .007),更有可能缓解(P = .008),疾病进程更有利(P = .011)。在过去两年中,EPPIC队列中有56%的人有带薪工作,而对照组为33%(P = .083)。与对照组相比,EPPIC每位患者每年的平均治疗成本为3445澳元,而对照组每位患者每年的成本为9503澳元。

结论

专门的早期精神病项目可以以标准公共精神卫生服务三分之一的成本实现更高的康复率。剩余的方法学局限性和样本量有限表明,需要进一步研究来验证这一发现。

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