Brunzell J D, Albers J J, Haas L B, Goldberg A P, Agadoa L, Sherrard D J
Metabolism. 1977 Aug;26(8):903-10. doi: 10.1016/0026-0495(77)90009-9.
Fasting levels of serum triglyceride, cholesterol, high-density lipoprotein (HDL), apoprotein A-I, HDL cholesterol, and HDL triglyceride were measured in 94 uremic males receiving maintenance hemodialysis and 6 uremic males receiving chronic peritoneal dialysis. These patients had higher serum triglyceride levels (p less than 0.001) and lower cholesterol levels (p less than 0.001) than normal controls. The dialysis patients treated with androgen or propranolol and those who were hypothyroid or diabetic had significantly higher triglyceride levels than the other dialysis subjects. The dialysis patients who had no additional secondary causes of hypertriglyceridemia had abnormalities in HDL; in comparison to normals and triglyceride-matched controls, these patients had elevated HDL triglyceride levels and low HDL cholesterol levels, despite similar HDL apoprotein A-I levels. The HDL cholesterol levels appeared to be lower in those patients than could be accounted for by their degree of hypertriglyceridemia.
对94名接受维持性血液透析的男性尿毒症患者和6名接受慢性腹膜透析的男性尿毒症患者测定了血清甘油三酯、胆固醇、高密度脂蛋白（HDL）、载脂蛋白A-I、HDL胆固醇和HDL甘油三酯的空腹水平。这些患者的血清甘油三酯水平高于正常对照组（p<0.001），胆固醇水平低于正常对照组（p<0.001）。接受雄激素或普萘洛尔治疗的透析患者以及甲状腺功能减退或糖尿病患者的甘油三酯水平明显高于其他透析患者。没有其他继发性高甘油三酯血症病因的透析患者HDL存在异常；与正常人和甘油三酯匹配的对照组相比，这些患者的HDL甘油三酯水平升高，HDL胆固醇水平降低，尽管HDL载脂蛋白A-I水平相似。这些患者的HDL胆固醇水平似乎低于其高甘油三酯血症程度所能解释的水平。
