Shinoda Kei, Imamura Yutaka, Matsuda Sayaka, Seki Maiko, Uchida Atsuro, Grossman Terry, Tsubota Kazuo
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Open Ophthalmol J. 2008 Aug 26;2:132-6. doi: 10.2174/1874364100802010132.
This reports the preliminary outcome of a transpalpebral electrical retinal stimulation therapy for age-related macular degeneration (ARMD).Twenty-one patients consisting of 16 with wet-type (Group-W) and 5 with dry-type (Group-D) ARMD with a mean age of 73.9 ± 9.5 years (range 51 to 85 years) were recruited for this study. Transpalpebral electrical retinal stimulation (20 minutes, 800 muA) was applied on the patients 4 times per day for up to 1 month. The mean best-corrected visual acuity (Early Treatment Diabetic Retinopathy Study [ETDRS] score) changed from 29.5±5.1 to 31.8±5.0 in Group-W and from 39.8±4.7 to 42.9±4.9 in Group-D. Neither ocular nor systemic adverse effects were observed with the exception of one patient who developed contact dermatitis. Due to several limitations such as lack of control, patients' learning effect, etc, the efficacy of the therapy could not be drawn. This preliminary study, however, showed that the transpalpebral electrical retinal stimulation therapy can be non-invasively applied on wet-type ARMD patients.
本文报告了经睑电视网膜刺激疗法治疗年龄相关性黄斑变性（ARMD）的初步结果。本研究招募了21例患者，其中16例为湿性（W组）、5例为干性（D组）ARMD患者，平均年龄73.9±9.5岁（范围51至85岁）。对患者进行经睑电视网膜刺激（20分钟，800微安），每天4次，持续1个月。W组的平均最佳矫正视力（早期糖尿病视网膜病变研究[ETDRS]评分）从29.5±5.1变为31.8±5.0，D组从39.8±4.7变为42.9±4.9。除1例发生接触性皮炎的患者外，未观察到眼部或全身不良反应。由于缺乏对照、患者学习效应等若干局限性，无法得出该疗法的疗效。然而，这项初步研究表明，经睑电视网膜刺激疗法可无创应用于湿性ARMD患者。
