Occupational Lung Disease Unit, Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham, UK.
Occup Med (Lond). 2009 Sep;59(6):418-23. doi: 10.1093/occmed/kqp083. Epub 2009 Jun 15.
To study serial peak expiratory flow (PEF) responses in a group of symptomatic detergent enzyme-exposed workers.
Workers were recruited from a biological detergent formulating and packaging company. Those with occupational asthma symptoms and/or specific IgE to a detergent enzyme were asked to complete 2 hourly PEF measurements for 4 weeks. Outputs from the Oasys program (Oasys score, rest-work score and rest-work difference in diurnal variation) assessed PEF response. These were then related to the levels of sensitization and current occupational exposure to detergent enzymes.
In all, 67/72 workers returned PEF records; 97% were able to return a record with at least four readings per day and 87% at least 3 weeks in length. Of total, 79% (n = 27) of those with a final diagnosis of occupational asthma had peak flow records confirming the disease using Oasys. PEF response was similar in those with high, medium and low levels of exposures and those with negative, low-moderate and high specific IgE levels.
The Oasys program is a sensitive tool for the diagnosis of detergent enzyme occupational asthma, but the levels of exposure and specific IgE sensitization to enzymes do not affect the magnitude of PEF response in symptomatic workers.
研究一组有症状的洗涤剂酶暴露工人的系列呼气峰流速（PEF）反应。
从一家生物洗涤剂配方和包装公司招募工人。有职业性哮喘症状和/或对洗涤剂酶特异性 IgE 的工人被要求完成 4 周的每 2 小时 PEF 测量。Oasys 程序（Oasys 评分、休息-工作评分和日间变异的休息-工作差异）评估了 PEF 反应。然后将这些反应与致敏水平和当前职业性接触洗涤剂酶的水平相关联。
共有 72 名工人中的 67 名返回了 PEF 记录；97%的人能够每天至少返回 4 次读数的记录，87%的人至少返回 3 周的记录。在最终诊断为职业性哮喘的人群中，有 79%（n=27）的人使用 Oasys 确认了疾病的峰流速记录。高、中、低暴露水平以及阴性、低-中度和高特异性 IgE 水平的人群的 PEF 反应相似。
Oasys 程序是诊断洗涤剂酶职业性哮喘的敏感工具，但暴露水平和对酶的特异性 IgE 致敏并不影响有症状工人的 PEF 反应幅度。
