Chapman H A, Hibbs J B
Science. 1977 Jul 15;197(4300):282-5. doi: 10.1126/science.195338.
The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.
巨噬细胞的杀肿瘤能力可被一种高分子量脂蛋白可逆性抑制，这种抑制作用似乎可通过用胆固醇富集巨噬细胞质膜来重现。第二种低分子量血清成分可增强巨噬细胞的细胞毒性。这些成分在正常血清中的存在表明此类因子在调节巨噬细胞功能方面具有生理作用。
