Hibbs J B, Taintor R R, Chapman H A, Weinberg J B
Science. 1977 Jul 15;197(4300):279-82. doi: 10.1126/science.327547.
Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.
活化巨噬细胞的肿瘤杀伤作用并非高度确定的生物学事件，而是受局部环境影响的一种相对能力。内在的巨噬细胞细胞毒性效应系统受到血清和其他环境因素的调节，这些因素可以增强或抑制肿瘤杀伤作用。只有当调节阈值降至极低水平时，活化巨噬细胞才会杀伤肿瘤细胞。
