用载体麻疹病毒初免并用单剂量乙型肝炎表面抗原加强免疫的恒河猴体内的保护性抗乙型肝炎病毒反应
Protective anti-hepatitis B virus responses in rhesus monkeys primed with a vectored measles virus and boosted with a single dose of hepatitis B surface antigen.
作者信息
Reyes-del Valle Jorge, Hodge Gregory, McChesney Michael B, Cattaneo Roberto
机构信息
Department of Molecular Medicine and Virology and Gene Therapy Graduate Track, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
出版信息
J Virol. 2009 Sep;83(17):9013-7. doi: 10.1128/JVI.00906-09. Epub 2009 Jun 17.
Abstract
The widely used hepatitis B virus (HBV) vaccine is based on three doses of hepatitis B surface antigen (HBsAg) protein. We previously showed that vectored measles viruses (MV) expressing HBsAg retain measles vaccine function in monkeys but do not induce a protective anti-HBs response in all animals. We show here that a single dose of HBsAg protein following a three-dose vaccination regimen with an optimized HBsAg-expressing MV elicits protective anti-HBs responses in all four vaccinated Rhesus monkeys. Vaccination strategies coupling the effective, long-term immunity elicited by the high-coverage MV vaccine to prophylactic HBV immunity are discussed.
摘要
广泛使用的乙型肝炎病毒（HBV）疫苗是基于三剂乙型肝炎表面抗原（HBsAg）蛋白。我们之前表明，表达HBsAg的载体麻疹病毒（MV）在猴子中保留了麻疹疫苗功能，但并非在所有动物中都能诱导出保护性抗-HBs反应。我们在此表明，在使用优化的表达HBsAg的MV进行三剂疫苗接种方案后，单剂量的HBsAg蛋白能在所有四只接种疫苗的恒河猴中引发保护性抗-HBs反应。文中讨论了将高覆盖率MV疫苗引发的有效、长期免疫与预防性HBV免疫相结合的疫苗接种策略。
相似文献
1
Protective anti-hepatitis B virus responses in rhesus monkeys primed with a vectored measles virus and boosted with a single dose of hepatitis B surface antigen.用载体麻疹病毒初免并用单剂量乙型肝炎表面抗原加强免疫的恒河猴体内的保护性抗乙型肝炎病毒反应
J Virol. 2009 Sep;83(17):9013-7. doi: 10.1128/JVI.00906-09. Epub 2009 Jun 17.
2
A vectored measles virus induces hepatitis B surface antigen antibodies while protecting macaques against measles virus challenge.一种载体麻疹病毒可诱导乙肝表面抗原抗体，同时保护猕猴免受麻疹病毒攻击。
J Virol. 2007 Oct;81(19):10597-605. doi: 10.1128/JVI.00923-07. Epub 2007 Jul 18.
3
Feasibility of Hepatitis B Vaccination by Microneedle Patch: Cellular and Humoral Immunity Studies in Rhesus Macaques.经皮微针贴片接种乙型肝炎疫苗的可行性：恒河猴的细胞和体液免疫研究。
J Infect Dis. 2019 Nov 6;220(12):1926-1934. doi: 10.1093/infdis/jiz399.
4
Recombinant vaccinia vector-based vaccine (Tiantan) boosting a novel HBV subunit vaccine induced more robust and lasting immunity in rhesus macaques.基于重组痘苗病毒载体的疫苗（天坛株）加强新型乙肝亚单位疫苗可在恒河猴中诱导更强大且持久的免疫反应。
Vaccine. 2017 Jun 5;35(25):3347-3353. doi: 10.1016/j.vaccine.2017.04.059. Epub 2017 May 6.
5
A vesicular stomatitis virus-based hepatitis B virus vaccine vector provides protection against challenge in a single dose.基于水疱性口炎病毒的乙型肝炎病毒疫苗载体可提供单次剂量接种的保护作用。
J Virol. 2010 Aug;84(15):7513-22. doi: 10.1128/JVI.00200-10. Epub 2010 May 26.
6
Poly(I:C)/alum mixed adjuvant priming enhances HBV subunit vaccine-induced immunity in mice when combined with recombinant adenoviral-based HBV vaccine boosting.聚肌苷酸-聚胞苷酸/氢氧化铝佐剂混合预刺激与重组腺病毒乙型肝炎疫苗加强免疫相结合增强 HBV 亚单位疫苗诱导的免疫应答。
PLoS One. 2013;8(1):e54126. doi: 10.1371/journal.pone.0054126. Epub 2013 Jan 15.
7
A recombinant measles virus expressing hepatitis B virus surface antigen induces humoral immune responses in genetically modified mice.一种表达乙型肝炎病毒表面抗原的重组麻疹病毒在转基因小鼠中诱导体液免疫反应。
J Virol. 1999 Jun;73(6):4823-8. doi: 10.1128/JVI.73.6.4823-4828.1999.
8
Comparison of a bacteriophage-delivered DNA vaccine and a commercially available recombinant protein vaccine against hepatitis B.一种噬菌体递送的DNA疫苗与一种市售重组蛋白乙肝疫苗的比较。
FEMS Immunol Med Microbiol. 2011 Mar;61(2):197-204. doi: 10.1111/j.1574-695X.2010.00763.x. Epub 2011 Jan 19.
9
Immune persistence 17 to 20 years after primary vaccination with recombination hepatitis B vaccine (CHO) and the effect of booster dose vaccination.初免重组乙型肝炎疫苗（CHO）后 17 至 20 年的免疫持久性和加强免疫接种的效果。
BMC Infect Dis. 2019 May 30;19(1):482. doi: 10.1186/s12879-019-4134-9.
10
Testing of CpG-optimized protein and DNA vaccines against the hepatitis B virus in chimpanzees for immunogenicity and protection from challenge.对经CpG优化的蛋白质和DNA疫苗进行黑猩猩乙型肝炎病毒免疫原性测试及攻毒保护试验。
Intervirology. 2006;49(3):144-51. doi: 10.1159/000089375.
引用本文的文献
1
Versatility of live-attenuated measles viruses as platform technology for recombinant vaccines.减毒活麻疹病毒作为重组疫苗平台技术的多功能性。
NPJ Vaccines. 2022 Oct 15;7(1):119. doi: 10.1038/s41541-022-00543-4.
2
Advances in RNA Viral Vector Technology to Reprogram Somatic Cells: The Paramyxovirus Wave.用于重编程体细胞的RNA病毒载体技术进展：副粘病毒浪潮。
Mol Diagn Ther. 2022 Jul;26(4):353-367. doi: 10.1007/s40291-022-00599-x. Epub 2022 Jun 28.
3
Engineering and combining oncolytic measles virus for cancer therapy.工程化和联合溶瘤麻疹病毒用于癌症治疗。
Cytokine Growth Factor Rev. 2020 Dec;56:39-48. doi: 10.1016/j.cytogfr.2020.07.005. Epub 2020 Jul 3.
4
Feasibility of Hepatitis B Vaccination by Microneedle Patch: Cellular and Humoral Immunity Studies in Rhesus Macaques.经皮微针贴片接种乙型肝炎疫苗的可行性：恒河猴的细胞和体液免疫研究。
J Infect Dis. 2019 Nov 6;220(12):1926-1934. doi: 10.1093/infdis/jiz399.
5
Vaccine platform recombinant measles virus.疫苗平台重组麻疹病毒
Virus Genes. 2017 Oct;53(5):733-740. doi: 10.1007/s11262-017-1486-3. Epub 2017 Jul 14.
6
Development of Recombinant Measles Virus-Based Vaccines.基于重组麻疹病毒的疫苗的研发。
Methods Mol Biol. 2017;1581:151-168. doi: 10.1007/978-1-4939-6869-5_9.
7
Generation of a More Immunogenic Measles Vaccine by Increasing Its Hemagglutinin Expression.通过增加血凝素表达来制备免疫原性更强的麻疹疫苗
J Virol. 2016 May 12;90(11):5270-5279. doi: 10.1128/JVI.00348-16. Print 2016 Jun 1.
8
Immunogenic Subviral Particles Displaying Domain III of Dengue 2 Envelope Protein Vectored by Measles Virus.免疫原性亚病毒颗粒展示了登革热 2 型包膜蛋白结构域 III，由麻疹病毒载体递呈。
Vaccines (Basel). 2015 Jul 3;3(3):503-18. doi: 10.3390/vaccines3030503.
9
Morbillivirus vaccines: recent successes and future hopes.麻疹病毒疫苗：近期的成功与未来的希望。
Vaccine. 2014 May 30;32(26):3155-61. doi: 10.1016/j.vaccine.2014.03.053. Epub 2014 Apr 3.
10
Sensitive detection of measles virus infection in the blood and tissues of humanized mouse by one-step quantitative RT-PCR.一步法实时定量 RT-PCR 检测人源化小鼠血液和组织中的麻疹病毒感染。
Front Microbiol. 2013 Oct 11;4:298. doi: 10.3389/fmicb.2013.00298. eCollection 2013.
本文引用的文献
1
Reverse genetics of measles virus and resulting multivalent recombinant vaccines: applications of recombinant measles viruses.麻疹病毒的反向遗传学及由此产生的多价重组疫苗：重组麻疹病毒的应用
Curr Top Microbiol Immunol. 2009;329:129-62. doi: 10.1007/978-3-540-70523-9_7.
2
Incremental system costs of introducing combined DTwP-hepatitis B-Hib vaccine into national immunization services in Ethiopia.在埃塞俄比亚将白喉、破伤风、百日咳-乙肝- Hib联合疫苗引入国家免疫规划的增量系统成本。
Vaccine. 2009 Feb 25;27(9):1426-32. doi: 10.1016/j.vaccine.2008.12.037. Epub 2009 Jan 13.
3
Implementation of newborn hepatitis B vaccination--worldwide, 2006.2006年全球新生儿乙型肝炎疫苗接种情况
MMWR Morb Mortal Wkly Rep. 2008 Nov 21;57(46):1249-52.
4
Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial.4.5月龄婴儿中标准埃登斯顿-萨格勒布麻疹疫苗接种的保护效力：一项随机临床试验的中期分析
BMJ. 2008 Jul 24;337:a661. doi: 10.1136/bmj.a661.
5
A vectored measles virus induces hepatitis B surface antigen antibodies while protecting macaques against measles virus challenge.一种载体麻疹病毒可诱导乙肝表面抗原抗体，同时保护猕猴免受麻疹病毒攻击。
J Virol. 2007 Oct;81(19):10597-605. doi: 10.1128/JVI.00923-07. Epub 2007 Jul 18.
6
Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation.麻疹病毒磷蛋白中的酪氨酸110是阻断STAT1磷酸化所必需的。
Virology. 2007 Mar 30;360(1):72-83. doi: 10.1016/j.virol.2006.09.049. Epub 2006 Nov 16.
7
A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents.美国消除乙型肝炎病毒感染传播的综合免疫策略：免疫实践咨询委员会（ACIP）的建议 第1部分：婴儿、儿童和青少年的免疫接种
MMWR Recomm Rep. 2005 Dec 23;54(RR-16):1-31.
8
A mathematical model to estimate global hepatitis B disease burden and vaccination impact.一种用于估计全球乙型肝炎疾病负担和疫苗接种影响的数学模型。
Int J Epidemiol. 2005 Dec;34(6):1329-39. doi: 10.1093/ije/dyi206. Epub 2005 Oct 25.
9
Hepatitis B surface antigen-specific T and B cell memory in individuals who had lost protective antibodies after hepatitis B vaccination.乙肝疫苗接种后失去保护性抗体的个体中的乙肝表面抗原特异性T细胞和B细胞记忆
Vaccine. 2006 Jan 30;24(5):572-7. doi: 10.1016/j.vaccine.2005.08.058. Epub 2005 Sep 1.
10
Hepatitis B vaccines.
Wkly Epidemiol Rec. 2004 Jul 9;79(28):255-63.
Zotero 插件