Young L S, Stevens P
J Infect Dis. 1977 Aug;136 Suppl:S174-80. doi: 10.1093/infdis/136.supplement.s174.
Two immunoprophylactic approaches to the control of infections caused by gramnegative bacilli were evaluated by study of experimental infections in animals. The core glycolipid antigen derived from the Re mutant of Salmonella minnesota R595 is shared by virtually all enteric bacteria, and immunization with this endotoxin protects against the hemodynamic sequelae of bacterial infection and pyrexia without enhancing intravascular clearance of bacteria. The degree of protection afforded by active and passive immunization with core glycolipid was significantly less than that conferred by type-specific immunization. Escherichia coli and Klebsiella pneumoniae share capsular antigens with some strains of Streptococcus pneumoniae; by the mechanism of enhanced opsonization, antibodies to S. pneumoniae may cross-protect against infection with E. coli or K. pneumoniae.
通过对动物实验性感染的研究，评估了两种控制革兰氏阴性杆菌引起感染的免疫预防方法。源自明尼苏达沙门氏菌R595的Re突变体的核心糖脂抗原几乎为所有肠道细菌所共有，用这种内毒素进行免疫可预防细菌感染和发热的血流动力学后遗症，而不会增强血管内细菌清除率。用核心糖脂进行主动和被动免疫所提供的保护程度明显低于型特异性免疫所提供的保护程度。大肠杆菌和肺炎克雷伯菌与某些肺炎链球菌菌株共享荚膜抗原；通过增强调理作用的机制，针对肺炎链球菌的抗体可能对大肠杆菌或肺炎克雷伯菌感染产生交叉保护作用。
