Simberkoff M S, Schiffman G S, Spicehandler J R, Moldover N H, Rahal J J
J Clin Microbiol. 1983 Jul;18(1):154-9. doi: 10.1128/jcm.18.1.154-159.1983.
Pneumococcal capsular polysaccharide vaccine was administered to 19 cirrhotic patients and to 25 control subjects. Radioimmunoassay antibody concentration and opsonic titers (OT) were measured in sera and ascites collected before and 3 to 4 weeks after inoculation. The geometric mean antibody concentrations in prevaccination sera from the cirrhotic patients were significantly increased to types 3, 4, 7F, 8, 9N, and 12F antigens, and in postinoculation sera their geometric mean antibody concentration was increased to types 3, 9N, and 12F antigens. OT to Streptococcus pneumoniae type 3 correlated with the radioimmunoassay antibody concentration in postinoculation sera. Of 14 cirrhotic subjects, 3 had OT of greater than or equal to 4 in prevaccination sera, and the highest OT and radioimmunoassay antibody concentration were observed in postinoculation specimens from this group. Antibody and OT against S. pneumoniae type 3 were also observed in ascitic specimens. These data suggest that cirrhotic subjects respond to pneumococcal capsular polysaccharide with antibodies in both serum and ascitic fluid. However, the protective efficacy of this antibody response must be assessed by larger prospective studies.
对19名肝硬化患者和25名对照受试者接种了肺炎球菌荚膜多糖疫苗。对接种前及接种后3至4周采集的血清和腹水进行放射免疫测定抗体浓度和调理素效价（OT）检测。肝硬化患者接种前血清中针对3型、4型、7F型、8型、9N型和12F型抗原的几何平均抗体浓度显著升高，接种后血清中针对3型、9N型和12F型抗原的几何平均抗体浓度升高。针对3型肺炎链球菌的OT与接种后血清中的放射免疫测定抗体浓度相关。14名肝硬化受试者中，3名接种前血清的OT大于或等于4，该组接种后标本中观察到最高的OT和放射免疫测定抗体浓度。在腹水标本中也观察到针对3型肺炎链球菌的抗体和OT。这些数据表明，肝硬化受试者血清和腹水中的抗体对肺炎球菌荚膜多糖有反应。然而，这种抗体反应的保护效果必须通过更大规模的前瞻性研究来评估。
