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低温器官保存的静态储存方法:现状与未来展望。

Hypothermic organ preservation by static storage methods: Current status and a view to the future.

机构信息

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr. W. Madison, WI 53706, USA.

出版信息

Cryobiology. 2010 Jul;60(3 Suppl):S13-9. doi: 10.1016/j.cryobiol.2009.06.004. Epub 2009 Jun 16.

Abstract

The donor organ shortage is the largest problem in transplantation today and is one where organ preservation technology has an important role to play. Static storage of solid organs, especially of the kidney, continues to be the most common method employed for storage and transport of organs from deceased donors. However, the increase in organs obtained from expanded criteria donors and donors with cardiac death provide new challenges in crafting effective preservation methods for the future. This article reviews the current status of static hypothermic storage methods and discusses potential avenues for future exploitation of this technology as the available organ pool is expanded into the more marginal donor categories.

摘要

供体器官短缺是当今移植领域面临的最大问题,而器官保存技术在此问题中发挥着重要作用。目前,固体器官(尤其是肾脏)的静态保存仍然是最常用的器官从已故供体获取后进行保存和运输的方法。然而,由于标准扩大化供体和心死亡供体获取的器官数量增加,为未来制定有效的保存方法带来了新的挑战。本文综述了目前的静态低温保存方法,并讨论了随着可供器官库向更边缘的供体类别扩展,未来对该技术进行开发利用的潜在途径。

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