Renuga S, Sahana N S, Suganya G, Kulkarni Meghashyama
Department of Oral Pathology and Microbiology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
J Oral Maxillofac Pathol. 2024 Apr-Jun;28(2):343-346. doi: 10.4103/jomfp.jomfp_330_22. Epub 2024 Jul 11.
Combined tumours are those composed of two benign tumours or a benign and malignant tumour or two malignant tumours occurring within the same tumour population. The incidence of combined tumours is very rare. Due to the rarity of these tumours, their biological behaviour remains unlashed. Incisional biopsy of a 48 years old female patient with single, diffuse tumour mass in the oral cavity showed combined tumour or collision tumour of malignant melanoma and squamous cell carcinoma. This was confirmed with immunohistochemistry study. The incidence of combined tumour of malignant melanoma and squamous cell carcinoma in oral cavity is extremely rare. To the best of our knowledge based on the previous literature records, this is the first case report of its kind where there is incidence in the human oral cavity.
复合肿瘤是指由两个良性肿瘤、一个良性肿瘤与一个恶性肿瘤或两个恶性肿瘤在同一肿瘤群体中发生所构成的肿瘤。复合肿瘤的发病率非常低。由于这些肿瘤较为罕见,它们的生物学行为仍未明确。一名48岁女性患者,口腔内有单个弥漫性肿瘤肿块,经切口活检显示为恶性黑色素瘤与鳞状细胞癌的复合肿瘤或碰撞瘤。这一诊断通过免疫组织化学研究得以证实。口腔内恶性黑色素瘤与鳞状细胞癌的复合肿瘤发病率极低。据我们所知,基于既往文献记录,这是人类口腔中出现该发病率的首例病例报告。