Ones Tunc, Dede Fuat, Gunal Dilek, Ekinci Gazanfer, Memis Hatice, Erdil Tanju Y, Inanir Sabahat, Turoglu Halil T
Kayasultan Sokak, Aydogan Sitesi, No. 72, A Blok, Daire: 5, Kozyatagi, Istanbul 34742, Turkey.
Ann Nucl Med. 2008 Jun;22(5):425-8. doi: 10.1007/s12149-007-0121-0. Epub 2008 Jul 4.
Fahr's disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifications than other imaging modalities. The clinical, CT scan, and 99(m)Tc-D,L-hexamethylpropylene amine oxime (99(m)Tc-HMPAO) brain perfusion single-photon emission computerized tomography (SPECT) findings in a 42-year-old woman with Fahr's disease are reported, and the clinical utility of 99(m)Tc-HMPAO SPECT findings in Fahr's disease is discussed in this article. In conclusion, 99(m)Tc-HMPAO brain perfusion SPECT seems to be useful in the clinical approach to Fahr's disease, and may provide more specific and clinically relevant information when compared with anatomical imaging.
法尔病是一种罕见的神经退行性综合征，其特征为基底神经节、小脑齿状核及相邻实质出现大量对称性脑内钙化。计算机断层扫描（CT）在检测这些颅内钙化方面比其他成像方式更为敏感。本文报告了一名42岁法尔病女性患者的临床、CT扫描及99m锝-D,L-六甲基丙烯胺肟（99mTc-HMPAO）脑灌注单光子发射计算机断层扫描（SPECT）结果，并探讨了99mTc-HMPAO SPECT结果在法尔病中的临床应用价值。总之，99mTc-HMPAO脑灌注SPECT在法尔病的临床诊断中似乎具有一定作用，与解剖学成像相比，可能提供更具特异性和临床相关性的信息。
