Bower R H, Sode J, Lipshutz W H
Am J Dig Dis. 1977 Aug;22(8):705-11. doi: 10.1007/BF01078350.
This report concerns gastric juice, plasma, and urinary levels of adenosine 3',5'-monophosphate (cAMP) in 27 subjects undergoing routine gastric analysis under maximum stimulation with betazole or pentagastrin. Cyclic AMP was measured by sensitive and specific radioimmunoassay. No increase in concentration of cAMP was noted in gastric juice, plasma, or urine following either betazole or pentagastrin stimulation. Betazole-stimulated human gastric acid secretion was associated with an increased cAMP output into the gastric juice (P less than 0.05). There was no change in cAMP output following pentagastrin stimulation. The peak acid output produced by pentagastrin and betazole was similar. The lack of increase in cAMP concentration lends support to the concept that cyclic AMP is not a primary mediator in the stimulation of gastric acid secretion by betazole or pentagastrin in the human. The physiologic significance of the increase in cAMP output following betazole stimulation remains unresolved.
本报告涉及27名接受倍他唑或五肽胃泌素最大刺激下常规胃液分析的受试者的胃液、血浆和尿中环磷酸腺苷（cAMP）水平。采用灵敏且特异的放射免疫分析法测定环磷酸腺苷。倍他唑或五肽胃泌素刺激后，胃液、血浆或尿液中的环磷酸腺苷浓度均未升高。倍他唑刺激人胃酸分泌与胃液中环磷酸腺苷输出增加相关（P<0.05）。五肽胃泌素刺激后环磷酸腺苷输出无变化。五肽胃泌素和倍他唑产生的最大胃酸分泌量相似。环磷酸腺苷浓度未升高支持了环磷酸腺苷不是人胃酸分泌受倍他唑或五肽胃泌素刺激的主要介质这一概念。倍他唑刺激后环磷酸腺苷输出增加的生理意义仍未明确。
