[药物名称]对代谢综合征的降压、抗血脂异常及肾脏保护作用。 （注：原文中“of”后面缺少具体药物名称等关键信息，以上译文是补充完整关键信息后的示意翻译）
Antihypertensive, antidyslipidemic, and renoprotective effects of on metabolic syndrome.
作者信息
Alejandrina Guzmán Hernández Elizabeth, Segura Cobos David, González Valle María Del Rosario, Del Carmen Benítez Flores José, Miguel Chávez Rubén San, Mondragón Leonardo Del Valle, Magos Guerrero Gil Alfonso, Sánchez Pedro López
机构信息
Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico,54090, Mexico.
Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, 54090, Mexico.
出版信息
Iran J Basic Med Sci. 2023 Apr;26(4):414-419. doi: 10.22038/IJBMS.2023.66530.14601.
OBJECTIVES
Metabolic syndrome is associated with the development of chronic kidney disease. "chaca" is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of on metabolic syndrome.
MATERIALS AND METHODS
For induction of metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of intragastrically (100 and 200 mg/kg/day) for 6 weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified.
RESULTS
Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of .
CONCLUSION
The ethanolic extract of showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.
目的
代谢综合征与慢性肾脏病的发生发展相关。“查卡”是一种在墨西哥用于治疗高血压及经验性治疗的药用植物。本研究考察了[植物名称未给出]乙醇提取物对代谢综合征的影响。
材料与方法
为诱导代谢综合征，使用20%果糖，将其添加到雄性Wistar大鼠的饮用水和食物中，持续12周。在给大鼠灌胃[植物名称未给出]乙醇提取物（100和200毫克/千克/天）6周后，测定血压。对血浆中的葡萄糖、胆固醇、甘油三酯、血管紧张素II、一氧化氮及血管紧张素1 - 7进行定量分析。对肾脏进行组织学研究，并对抗氧化酶的活性进行定量分析。
结果
患有代谢综合征的大鼠出现肥胖、动脉高血压、血脂异常及肾脏损伤，其特征为增殖性肾小球肾炎、坏死以及抗氧化酶活性降低。[植物名称未给出]乙醇提取物显著改善了这些改变。
结论
[植物名称未给出]乙醇提取物具有抗血脂异常、降压、抗氧化及肾脏保护作用。
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