用于骨组织工程应用的新型几丁质/纳米二氧化硅复合支架
Novel chitin/nanosilica composite scaffolds for bone tissue engineering applications.
作者信息
Madhumathi K, Sudheesh Kumar P T, Kavya K C, Furuike T, Tamura H, Nair S V, Jayakumar R
机构信息
Amrita Centre for Nanosciences, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682 026, India.
出版信息
Int J Biol Macromol. 2009 Oct 1;45(3):289-92. doi: 10.1016/j.ijbiomac.2009.06.009. Epub 2009 Jun 21.
Biopolymers like chitin are widely investigated as scaffolds in bone tissue engineering. Its properties like biocompatibility, biodegradability, non-toxicity, wound healing ability, antibacterial activity, hemostatic property, etc., are widely known. However, these materials are not much bioactive. Addition of material like silica can improve the bioactivity and biocompatibility of chitin. In this work, chitin composite scaffolds containing nanosilica were prepared using chitin hydrogel and their bioactivity, swelling ability and cytotoxicity was analyzed in vitro. These scaffolds were found to be bioactive in simulated body fluid (SBF) and biocompatible when tested with MG 63 cell line. These results suggest that chitin/nanosilica composite scaffolds can be useful for bone tissue engineering applications.
几丁质等生物聚合物作为骨组织工程中的支架材料受到广泛研究。其生物相容性、生物降解性、无毒性、伤口愈合能力、抗菌活性、止血性能等特性广为人知。然而，这些材料的生物活性并不高。添加二氧化硅等材料可以提高几丁质的生物活性和生物相容性。在这项工作中，使用几丁质水凝胶制备了含有纳米二氧化硅的几丁质复合支架，并对其生物活性、溶胀能力和细胞毒性进行了体外分析。当用MG 63细胞系进行测试时，发现这些支架在模拟体液（SBF）中具有生物活性且具有生物相容性。这些结果表明，几丁质/纳米二氧化硅复合支架可用于骨组织工程应用。
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