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几丁质纳米纤维：制备及其在生物医学及其他领域应用的最新进展

Chitin nanofibers: recent advances in preparation and applications in biomedical and beyond.

作者信息

Islam M Ariful, Hasan M Nahid, Evan M Sadik Hussain, Uddin M Jalal, Tulin Wahid Salekin, Islam M Saydul, Khandaker Mayeen Uddin, Rahman Ismail M M, Chowdhury Faisal I

机构信息

Nanotechnology, Renewable Energy and Catalysis Laboratory, Department of Chemistry, University of Chittagong Chattogram 4331 Bangladesh

Graduate School of Natural Science and Technology, Kanazawa University Kakuma Kanazawa 920-1192 Japan.

出版信息

RSC Adv. 2025 May 19;15(19):14655-14690. doi: 10.1039/d4ra06937d. eCollection 2025 May 6.

DOI:10.1039/d4ra06937d
PMID:40390794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12086821/
Abstract

Chitin and chitosan-based nanofibers (ChNFs), derived from renewable sources, have emerged as promising biomaterials due to their unique properties such as high surface area, porosity, biocompatibility, and biodegradability. This review provides a comprehensive overview of ChNF extraction and synthesis, focusing on both top-down and bottom-up approaches. A comparative analysis of these methods is presented, highlighting the challenges, opportunities, environmental impact, cost-effectiveness, and quality consistency associated with each. The advantages of ChNFs over similar nanomaterials are elucidated, emphasizing their diverse applications in biomedical and environmental fields. Biomedical applications include drug delivery, tissue engineering, cancer treatment, wound healing, and biosensing. Environmental applications encompass water treatment, air filtration, agriculture, and biodegradable packaging. Despite their potential, challenges remain, including low solubility, unstable mechanical properties, and inconsistent quality, which limit their widespread use. This review also examines recent advancements in ChNF research, aiming to guide the development of efficient and environmentally friendly synthesis methods. By encouraging innovation in ChNF-based nanotechnologies, this research contributes to a more sustainable future.

摘要

源自可再生资源的几丁质和壳聚糖基纳米纤维（ChNFs），因其具有高比表面积、孔隙率、生物相容性和生物降解性等独特性能，已成为很有前景的生物材料。本综述全面概述了ChNF的提取与合成，重点关注自上而下和自下而上的方法。对这些方法进行了比较分析，突出了每种方法所涉及的挑战、机遇、环境影响、成本效益和质量一致性。阐述了ChNFs相对于类似纳米材料的优势，强调了它们在生物医学和环境领域的多种应用。生物医学应用包括药物递送、组织工程、癌症治疗、伤口愈合和生物传感。环境应用涵盖水处理、空气过滤、农业和可生物降解包装。尽管它们具有潜力，但挑战依然存在，包括低溶解度、不稳定的机械性能和不一致的质量，这限制了它们的广泛应用。本综述还考察了ChNF研究的最新进展，旨在指导高效且环境友好的合成方法的开发。通过鼓励基于ChNF的纳米技术创新，本研究为更可持续的未来做出贡献。

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