铅对免疫及病毒干扰素产生的影响。
The effect of lead on immune and viral interferon production.
作者信息
Blakley B R, Archer D L, Osborne L
出版信息
Can J Comp Med. 1982 Jan;46(1):43-6.
Female BDF1 mice were exposed to lead acetate in the drinking water at concentrations ranging form 0 to 1000 micrograms/mL lead for three weeks. The mice tolerated these levels of lead exposure without exhibiting signs of clinical toxicity. Weight gains were not affected by lead exposure. The production of viral interferon induced by the oral administration of tilorone was not altered by lead exposure. The T-lymphocyte mitogens concanavalin A, phytohemagglutinin and staphylococcal enterotoxin A induced immune interferon to varying degrees, with concanavalin A and staphylococcal enterotoxin A exhibiting the most potent induction capabilities. The production of immune interferon induced by T-lymphocyte mitogens was not suppressed by lead exposure.
雌性BDF1小鼠饮用含铅浓度为0至1000微克/毫升醋酸铅的水，持续三周。这些小鼠耐受这些铅暴露水平，未表现出临床毒性迹象。体重增加不受铅暴露影响。口服泰洛龙诱导产生的病毒干扰素的生成未因铅暴露而改变。T淋巴细胞有丝分裂原刀豆球蛋白A、植物血凝素和葡萄球菌肠毒素A能不同程度地诱导免疫干扰素，其中刀豆球蛋白A和葡萄球菌肠毒素A的诱导能力最强。T淋巴细胞有丝分裂原诱导产生的免疫干扰素的生成未因铅暴露而受到抑制。
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