Suwansirikul S, Rao N, Dowling J N, Ho M
Arch Intern Med. 1977 Aug;137(8):1026-9.
Forty-seven patients who underwent renal transplants were followed clinically and were examined for serologic or virologic evidence of cytomegalovirus (CMV) infection. There were 18 cases of primary infection and ten cases of secondary infection. These findings were based on whether the patient was seronegative or seropositive prior to transplantation. Thirteen patients with primary infection and only one patient with secondary infection had two or more of the following manifestations that are temporally associated with laboratory evidence of infection: fever, leukopenia, atypical lymphocytes, lymphocytosis, hepatosplenomegaly, myalgia, arthralgia, and pneumonitis. Five patients with primary infections, one of whom died with disseminated disease, were recognized by attending physicians as having CMV disease. Since primary infection is though to be largely due to virus transmitted by the kidney of a seropositive donor, it may be possible to prevent symptomatic primary infection by using only seronegative donors for seronegative recipients.
对47例接受肾移植的患者进行了临床随访，并检查了巨细胞病毒（CMV）感染的血清学或病毒学证据。有18例原发性感染和10例继发性感染。这些发现基于患者移植前血清学阴性或阳性。13例原发性感染患者和仅1例继发性感染患者出现了两种或更多种与感染实验室证据在时间上相关的以下表现：发热、白细胞减少、非典型淋巴细胞、淋巴细胞增多、肝脾肿大、肌痛、关节痛和肺炎。5例原发性感染患者，其中1例死于播散性疾病，被主治医生诊断为患有CMV疾病。由于原发性感染被认为主要是由于血清学阳性供体的肾脏传播的病毒引起的，因此对于血清学阴性的受者仅使用血清学阴性的供体可能有可能预防有症状的原发性感染。
