细胞间的竞争性相互作用：死亡、生长与空间分布

Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Science. 2009 Jun 26;324(5935):1679-82. doi: 10.1126/science.1163862.

Competitive interactions between cells are the basis of many homeostatic processes in biology. Some of the best-described cases of competition between cells occur in Drosophila: cell competition, whereby somatic cells within a growing epithelium compete with one another for contribution to the adult, and stem cell competition, in which germline or somatic stem cells vie for residency in the niche. Both types of competition are conserved physiological processes, with much to tell us about how cellular neighborhoods influence cell behavior, and have importance to stem cell biology, regeneration and transplantation, and cancer.

细胞间的竞争性相互作用是生物学中许多稳态过程的基础。细胞间竞争的一些描述得最为详尽的例子发生在果蝇中：细胞竞争，即生长上皮内的体细胞相互竞争以对成虫做出贡献；以及干细胞竞争，即生殖系或体干细胞争夺在生态位中的驻留位置。这两种竞争都是保守的生理过程，能让我们深入了解细胞邻域如何影响细胞行为，并且对干细胞生物学、再生与移植以及癌症都具有重要意义。