Leposavić Ivana, Leposavić Ljubica, Jasović-Gasić Miroslava
The Institute of Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia.
Psychiatr Danub. 2009 Jun;21(2):166-73.
Previous studies concerned with neuropsychological aspect of delusions, were mainly focused on specific forms of this disorder, such as Cotard or Capgras type of delusions. Comparatively small numbers of investigations were concerned with cognitive deficiencies accompanying the delusions. The substance of this study includes the detection of neuropsychological dysfunctions in patients with delusional disorder, and tracing of these cognitive distortions to appropriate brain regions.
The investigation is designed as a comparative study. Inpatients with delusion are compared with normal subjects from the aspect of the following cognitive functions: attention, memory, visuospatial and visuoconstruction organization, executive ability, verbal divergent thinking.
Attention, memory (verbal modality) and psychomotor skill tasks are most susceptible to delusional effects.
The neuropsychological profile of patients with delusional disorder includes impediment of complex attention modalities. From this primary disorder, there also stems a disorder of verbal memory in the sense of reduced recognition. These cognitive distortions suggest a dysfunction of the anterior regions of the cerebrum, mainly of the prefrontal and sinistral temporal regions.
以往关于妄想症神经心理学方面的研究主要集中在该障碍的特定形式，如科塔尔或卡普格拉妄想症类型。相对较少的研究关注伴随妄想出现的认知缺陷。本研究的内容包括检测妄想症患者的神经心理功能障碍，并将这些认知扭曲追溯到相应的脑区。
本研究设计为一项对比研究。将妄想症住院患者与正常受试者在以下认知功能方面进行比较：注意力、记忆力、视觉空间与视觉构建组织能力、执行能力、言语发散性思维。
注意力、记忆力（言语模式）和心理运动技能任务最易受到妄想的影响。
妄想症患者的神经心理学特征包括复杂注意力模式的障碍。从这种原发性障碍还会衍生出言语记忆障碍，表现为识别能力下降。这些认知扭曲表明大脑前部区域功能失调，主要是前额叶和左侧颞叶区域。
