Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM) University of Granada, Granada, Spain.
PLoS One. 2013 Jul 2;8(7):e67341. doi: 10.1371/journal.pone.0067341. Print 2013.
Delusional disorder has been traditionally considered a psychotic syndrome that does not evolve to cognitive deterioration. However, to date, very little empirical research has been done to explore cognitive executive components and memory processes in Delusional Disorder patients. This study will investigate whether patients with delusional disorder are intact in both executive function components (such as flexibility, impulsivity and updating components) and memory processes (such as immediate, short term and long term recall, learning and recognition).
A large sample of patients with delusional disorder (n = 86) and a group of healthy controls (n = 343) were compared with regard to their performance in a broad battery of neuropsychological tests including Trail Making Test, Wisconsin Card Sorting Test, Colour-Word Stroop Test, and Complutense Verbal Learning Test (TAVEC).
When compared to controls, cases of delusional disorder showed a significantly poorer performance in most cognitive tests. Thus, we demonstrate deficits in flexibility, impulsivity and updating components of executive functions as well as in memory processes. These findings held significant after taking into account sex, age, educational level and premorbid IQ.
Our results do not support the traditional notion of patients with delusional disorder being cognitively intact.
妄想障碍传统上被认为是一种不会发展为认知功能恶化的精神病综合征。然而，迄今为止，很少有实证研究探索妄想障碍患者的认知执行成分和记忆过程。本研究将调查妄想障碍患者在执行功能成分（如灵活性、冲动性和更新成分）和记忆过程（如即时、短期和长期回忆、学习和识别）方面是否完整。
将大量妄想障碍患者（n=86）与一组健康对照组（n=343）进行比较，比较他们在广泛的神经心理学测试中的表现，包括连线测试、威斯康星卡片分类测试、颜色-词语斯特鲁普测试和马德里认知评估测试（TAVEC）。
与对照组相比，妄想障碍患者在大多数认知测试中表现明显较差。因此，我们证明了执行功能的灵活性、冲动性和更新成分以及记忆过程存在缺陷。在考虑性别、年龄、教育水平和发病前智商后，这些发现仍然具有统计学意义。
我们的结果不支持妄想障碍患者认知完整的传统观念。
