Jeon Jeong Hee, Kwon Sang-Chul, Park Dongsun, Shin Sunhee, Jeong Jae-Hyun, Park So-Young, Hwang Seock-Yeon, Kim Yun-Bae, Joo Seong Soo
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.
Arch Pharm Res. 2009 Jun;32(6):823-30. doi: 10.1007/s12272-009-1602-6. Epub 2009 Jun 26.
Rosa rugosa is a species of rose native to eastern Asia. The root of R. rugosa has been used to treat diabetes mellitus, pain and chronic inflammatory disease, and a R. rugosa petal extract has a strong anti-oxidant effect. In the present study, we examined if solvent fractions from white rose petal extract (WRPE) had any anti-allergic or anti-atopic effects not previously reported. WRPE and butanol and hexane fractions effectively reduced systemic anaphylactic reactions and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis in mice, with the greatest inhibition observed for the hexane fraction. In addition, a significant reduction of scratching behavior by mice after histamine injection suggested this fraction's potential anti-allergic effect. At the cell level, the hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 cytokines produced by T helper cells (type 1 and 2). These results strongly support that the hexane fraction may have an effect on atopic dermatitis, as these 2 cell types play central roles in the pathogenesis of atopic dermatitis. In conclusion, these results suggest that either the hexane fraction or one of its components may be beneficial for the treatment of allergic diseases, including atopic dermatitis.
玫瑰是一种原产于东亚的蔷薇属植物。玫瑰的根已被用于治疗糖尿病、疼痛和慢性炎症性疾病，玫瑰花瓣提取物具有很强的抗氧化作用。在本研究中，我们研究了白玫瑰花瓣提取物（WRPE）的溶剂组分是否具有此前未报道的抗过敏或抗特应性作用。WRPE以及丁醇和己烷组分可有效减轻小鼠的全身过敏反应和抗二硝基苯基（DNP）IgE介导的被动皮肤过敏反应，其中己烷组分的抑制作用最强。此外，组胺注射后小鼠抓挠行为的显著减少表明该组分具有潜在的抗过敏作用。在细胞水平上，己烷组分显著抑制RBL-2H3肥大细胞释放β-己糖胺酶，并抑制T辅助细胞（1型和2型）产生的mRNA干扰素-γ和白细胞介素-4细胞因子的表达。由于这两种细胞类型在特应性皮炎的发病机制中起核心作用，这些结果有力地支持了己烷组分可能对特应性皮炎有作用。总之，这些结果表明，己烷组分或其成分之一可能对包括特应性皮炎在内的过敏性疾病的治疗有益。
