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玫瑰花瓣正丁醇萃取物对大脑中动脉阻塞模型的神经保护作用。

Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model.

机构信息

College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.

College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.

出版信息

Biomol Ther (Seoul). 2013 Nov;21(6):454-61. doi: 10.4062/biomolther.2013.067.

DOI:10.4062/biomolther.2013.067
PMID:24404336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3879917/
Abstract

The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.

摘要

研究了白玫瑰花瓣提取物（WRPE）正丁醇馏分（WRPE-BF）在大脑中动脉闭塞（MCAO）模型中的神经保护作用。7 周龄雄性大鼠经口给予 WRPE-BF 2 周，并进行 MCAO 2 小时，然后再进行再灌注。24 小时后，WRPE-BF 预处理以剂量依赖性方式明显改善了 MCAO 引起的行为功能障碍。此外，高剂量的 WRPE-BF 不仅减少了梗塞面积，而且还有效减少了星形胶质细胞增生。WRPE-BF 处理显著抑制了 MCAO 模型中诱导型一氧化氮合酶、环氧化酶-2 和神经胶质纤维酸性蛋白的表达。值得注意的是，WRPE-BF 降低了中风挑战大脑纹状体和侧脑室下区的一氧化氮和丙二醛水平。这些数据表明，WRPE-BF 可能通过抗氧化和抗炎活性发挥其对缺血再灌注脑损伤的神经保护作用，并且可能是缺血性中风的一个很好的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/17431fee3b90/ooomb4-21-454-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/7c6db3401202/ooomb4-21-454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/ad5d10fed27a/ooomb4-21-454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/8784edb4fed6/ooomb4-21-454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/dbc035da6ac1/ooomb4-21-454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/17431fee3b90/ooomb4-21-454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/31f80ae0efee/ooomb4-21-454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/603f133fd574/ooomb4-21-454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/7c6db3401202/ooomb4-21-454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/ad5d10fed27a/ooomb4-21-454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/8784edb4fed6/ooomb4-21-454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/dbc035da6ac1/ooomb4-21-454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de4a/3879917/17431fee3b90/ooomb4-21-454-g007.jpg

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