Hegde Rajesh N, Shetti Nagaraj P, Nandibewoor Sharanappa T
P.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India.
Talanta. 2009 Jul 15;79(2):361-8. doi: 10.1016/j.talanta.2009.03.064. Epub 2009 Apr 5.
A simple and rapid electrochemical method was developed for the determination of trace-level trazodone, based on the excellent properties of multi-walled carbon nanotubes (MWCNTs). The MWCNT-modified glassy carbon electrode was constructed and the electrochemical behavior of trazodone was investigated in detail. The cyclic voltammetric results indicate that MWCNT-modified glassy carbon electrode can remarkably enhance electrocatalytic activity towards the oxidation of trazodone in neutral solutions. It leads to a considerable improvement of the anodic peak current for trazodone, and allows the development of a highly sensitive voltammetric sensor for the determination of trazodone. Trazodone could effectively accumulate at this electrode and produce two anodic peaks at about 0.73 V and 1.00 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the trazodone determination by differential-pulse voltammetry. Under optimized conditions, the concentration range and detection limit are 0.2-10 microM and 24 nM, respectively for trazodone. The proposed method was successfully applied to trazodone determination in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in urine as a real sample.
基于多壁碳纳米管（MWCNTs）的优异性能，开发了一种简单快速的电化学方法用于测定痕量曲唑酮。构建了MWCNT修饰的玻碳电极，并详细研究了曲唑酮的电化学行为。循环伏安法结果表明，MWCNT修饰的玻碳电极能显著增强对中性溶液中曲唑酮氧化的电催化活性。这导致曲唑酮阳极峰电流有相当大的提高，并使得能够开发出一种用于测定曲唑酮的高灵敏度伏安传感器。曲唑酮能在该电极上有效富集，并在约0.73 V和1.00 V处产生两个阳极峰。通过差分脉冲伏安法进一步利用这种电催化行为作为曲唑酮测定的灵敏检测方案。在优化条件下，曲唑酮的浓度范围和检测限分别为0.2 - 10 microM和24 nM。该方法成功应用于药物样品中曲唑酮的测定。作为实际样品，已对该传感器检测尿液中分析物的分析性能进行了评估。
