Salama Fathy M, Attia Khalid A, Said Ragab A, El-Olemy Ahmed, Abdel-Raoof Ahmed M
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University 11751 Nasr City Cairo Egypt
RSC Adv. 2018 Mar 23;8(21):11517-11527. doi: 10.1039/c8ra00745d. eCollection 2018 Mar 21.
In the present study, screen-printed electrodes unmodified and chemically modified with gold nanoparticles were used as sensitive electrochemical sensors for the determination of trazodone hydrochloride. The sensors were based on the use of a tetraphenylborate ion association complex as an electroactive material in screen-printed electrodes with dioctyl phthalate (DOP) as a solvent mediator modified with gold nanoparticles which improve the electrode conductivity and enhance the surface area. The sensors displayed a stable response for 5, 6 and 7 months with a reproducible potential and linear response over the concentration range 1 × 10-1 × 10 mol L at 25 ± 1 °C with Nernstian slopes of 57.50 ± 0.66, 58.30 ± 0.45 and 59.05 ± 0.58 mV per decade and detection limits of 7.9 × 10, 7.6 × 10 and 6.8 × 10 mol L for sensor 1, 2 and 3 respectively. The analytical performance of the screen printed electrodes in terms of selectivity coefficients for trazodone hydrochloride relative to the number of potentially interfering substances was investigated. The proposed method has been applied successfully for the analysis of the drug in its pure and dosage forms and there is no interference from any common pharmaceutical additives.
在本研究中，未修饰和用金纳米粒子化学修饰的丝网印刷电极被用作测定盐酸曲唑酮的灵敏电化学传感器。这些传感器基于使用四苯基硼酸根离子缔合络合物作为电活性材料，在以邻苯二甲酸二辛酯（DOP）作为溶剂介质的丝网印刷电极中，该电极用金纳米粒子修饰，可提高电极导电性并增加表面积。在25±1℃下，传感器在5、6和7个月内显示出稳定的响应，具有可重现的电位和在1×10⁻¹×10 mol/L浓度范围内的线性响应，传感器1、2和3的能斯特斜率分别为每十年57.50±0.66、58.30±0.45和59.05±0.58 mV，检测限分别为7.9×10⁻⁶、7.6×10⁻⁶和6.8×10⁻⁶ mol/L。研究了丝网印刷电极相对于多种潜在干扰物质的盐酸曲唑酮选择性系数方面的分析性能。所提出的方法已成功应用于该药物纯品和剂型的分析，且不受任何常见药用辅料的干扰。
