美国国立卫生研究院-美国退休人员协会饮食与健康研究中的膳食脂肪酸与胰腺癌

Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study.

作者信息

Thiébaut Anne C M, Jiao Li, Silverman Debra T, Cross Amanda J, Thompson Frances E, Subar Amy F, Hollenbeck Albert R, Schatzkin Arthur, Stolzenberg-Solomon Rachael Z

机构信息

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

出版信息

J Natl Cancer Inst. 2009 Jul 15;101(14):1001-11. doi: 10.1093/jnci/djp168. Epub 2009 Jun 26.

DOI:10.1093/jnci/djp168

PMID:19561318

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2724851/

Abstract

BACKGROUND

Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive.

METHODS

We prospectively analyzed the association between intakes of fat, fat subtypes, and fat food sources and exocrine pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study, a US cohort of 308 736 men and 216 737 women who completed a 124-item food frequency questionnaire in 1995-1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models, with adjustment for energy intake, smoking history, body mass index, and diabetes. Statistical tests were two-sided.

RESULTS

Over an average follow-up of 6.3 years, 865 men and 472 women were diagnosed with exocrine pancreatic cancer (45.0 and 34.5 cases per 100 000 person-years, respectively). After multivariable adjustment and combination of data for men and women, pancreatic cancer risk was directly related to the intakes of total fat (highest vs lowest quintile, 46.8 vs 33.2 cases per 100 000 person-years, HR = 1.23, 95% CI = 1.03 to 1.46; P(trend) = .03), saturated fat (51.5 vs 33.1 cases per 100 000 person-years, HR = 1.36, 95% CI = 1.14 to 1.62; P(trend) < .001), and monounsaturated fat (46.2 vs 32.9 cases per 100 000 person-years, HR = 1.22, 95% CI = 1.02 to 1.46; P(trend) = .05) but not polyunsaturated fat. The associations were strongest for saturated fat from animal food sources (52.0 vs 32.2 cases per 100 000 person-years, HR = 1.43, 95% CI = 1.20 to 1.70; P(trend) < .001); specifically, intakes from red meat and dairy products were both statistically significantly associated with increased pancreatic cancer risk (HR = 1.27 and 1.19, respectively).

CONCLUSION

In this large prospective cohort with a wide range of intakes, dietary fat of animal origin was associated with increased pancreatic cancer risk.

摘要

背景

以往关于饮食脂肪（一种可改变的风险因素）与胰腺癌关系的研究尚无定论。

方法

在美国国立卫生研究院-美国退休人员协会饮食与健康研究中，我们前瞻性分析了脂肪、脂肪亚型和脂肪食物来源的摄入量与外分泌性胰腺癌之间的关联。该研究是一项队列研究，纳入了308736名男性和216737名女性，他们于1995 - 1996年完成了一份包含124个项目的食物频率问卷。使用Cox比例风险回归模型计算风险比（HRs）和95%置信区间（CIs），并对能量摄入、吸烟史、体重指数和糖尿病进行了调整。统计检验为双侧检验。

结果

在平均6.3年的随访期内，865名男性和472名女性被诊断为外分泌性胰腺癌（分别为每10万人年45.0例和34.5例）。在对男性和女性的数据进行多变量调整和合并后，胰腺癌风险与总脂肪摄入量直接相关（最高五分位数与最低五分位数相比，每10万人年分别为46.8例和33.2例，HR = 1.23，95% CI = 1.03至1.46；P（趋势）= 0.03）、饱和脂肪（每10万人年51.5例和33.1例，HR = 1.36，95% CI = 1.14至1.62；P（趋势）< 0.001）和单不饱和脂肪（每10万人年46.2例和32.9例，HR = 1.22，95% CI = 1.02至1.46；P（趋势）= 0.05），但与多不饱和脂肪无关。来自动物食物来源的饱和脂肪的关联最为显著（每10万人年52.0例和32.2例，HR = 1.43，95% CI = 1.20至1.70；P（趋势）< 0.001）；具体而言，红肉和乳制品的摄入量均与胰腺癌风险增加在统计学上显著相关（HR分别为1.27和1.19）。