Le Ngoan Tran, Pham Yen Thi-Hai, Le Linh Thuy, Nguyen Dai Duc, Guo Xingyi, Luu Hung N
Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA.
Eur J Nutr. 2025 Aug 31;64(6):268. doi: 10.1007/s00394-025-03773-z.
Monounsaturated fatty acids (MUFA) are considered healthy fats with a single double bond in the constituent fatty acids and have antioxidant properties, cholesterol-lowering properties, and ability to reduce chronic inflammation. Evidence regarding the effect of MUFA intake on gastric cancer risk is inconclusive among diverse populations. Given the differences in dietary composition among different racial/ethnicities, we aimed to evaluate the association between MUFA intake and risk of gastric cancer in a hospital-based case-control study comprising 1182 incident cases of gastric cancer and 2965 controls in Vietnam.
MUFA intake was quantified using a semi-quantitative validated food frequency questionnaire (FFQ). We used an unconditional logistic regression model to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer in relation to MUFA intake.
Overall, there was an inverse association between MUFA intake and gastric cancer risk (OR = 0.75, 95% CI 0.67-0.84; P < 0.001). Compared with the lowest quintile, the ORs (95% CIs) of gastric cancer for quintiles 2, 3, 4, and 5 of the MUFA intake were 0.86 (0.68-1.03), 0.65 (0.51-0.81), 0.53 (0.41-0.67) and 0.43 (0.33-0.57), respectively. A similar pattern was observed in both sexes and in individuals aged < 60 years and those aged 60 years or older.
In summary, MUFA intake was associated with a reduced risk of gastric cancer in the Vietnamese population, regardless of sex or age. Our findings have great implications for gastric cancer prevention and control programs in low-middle-income countries and similar limited-resource settings.
单不饱和脂肪酸（MUFA）被认为是健康脂肪，其构成脂肪酸中含有一个双键，具有抗氧化特性、降低胆固醇特性以及减轻慢性炎症的能力。关于不同人群中MUFA摄入量对胃癌风险影响的证据尚无定论。鉴于不同种族/民族的饮食组成存在差异，我们旨在通过一项基于医院的病例对照研究，评估越南1182例胃癌新发病例和2965例对照中MUFA摄入量与胃癌风险之间的关联。
使用经过验证的半定量食物频率问卷（FFQ）对MUFA摄入量进行量化。我们采用无条件逻辑回归模型计算与MUFA摄入量相关的胃癌风险的比值比（OR）和95%置信区间（CI）。
总体而言，MUFA摄入量与胃癌风险呈负相关（OR = 0.75，95% CI 0.67 - 0.84；P < 0.001）。与最低五分位数相比，MUFA摄入量的第2、3、4和5五分位数的胃癌OR（95% CI）分别为0.86（0.68 - 1.03）、0.65（0.51 - 0.81）、0.53（0.41 - 0.67）和0.43（0.33 - 0.57）。在男性和女性、年龄<60岁的个体以及年龄≥60岁的个体中均观察到类似模式。
总之，在越南人群中，无论性别或年龄，MUFA摄入量与胃癌风险降低相关。我们的研究结果对中低收入国家和类似资源有限环境中的胃癌预防和控制计划具有重要意义。
