McKenna R W, Parkin J, Gajl-Peczalska K J, Kersey J H, Brunning R D
Blood. 1977 Sep;50(3):505-15.
Atypical lymphocytes from nine young adults with acute infectious mononucleosis (IM) were studied for morphologic, ultrastructural, cytochemical, and membrane surface marker characteristics. There was an absolute increase in T lymphocytes in the patients. Atypical lymphocytes accounted for 83%-96% of the lymphocyte population. These lymphocytes contained cytoplasmic inclusions which ranged in size from 1000 to 6000 A, were usually membrane bound, and consisted of parallel arrays of microtubulelike structures. The inclusions, which have been referred to as parallel tubular arrays (PTA), were found in 15%-75% of the lymphocytes from the IM patients. Ultrastructural cytochemical methods demonstrated acid phosphatase activity within many of the membrane-bound PTA. The function of the PTA is unknown. Since they were observed only in the lymphocytes which appeared to correspond to the atypical lymphocytes on light microscopy, the majority of which typed as T cells, there appears to be an association between PTA and T lymphocytes. It is possible that PTA identify a specific subset of T lymphocytes which is expanded in IM. Alternatively, PTA may be a transient finding in lymphocytes appearing only in certain biologic states of the cell such as during T-lymphocyte activation.
对9名患有急性传染性单核细胞增多症（IM）的年轻成年人的非典型淋巴细胞进行了形态学、超微结构、细胞化学和膜表面标志物特征研究。患者体内T淋巴细胞绝对数量增加。非典型淋巴细胞占淋巴细胞总数的83%-96%。这些淋巴细胞含有细胞质内含物，大小在1000至6000埃之间，通常有膜包裹，由微管样结构的平行排列组成。这些内含物被称为平行管状排列（PTA），在IM患者15%-75%的淋巴细胞中被发现。超微结构细胞化学方法显示许多有膜包裹的PTA内有酸性磷酸酶活性。PTA的功能尚不清楚。由于仅在光镜下看似与非典型淋巴细胞相对应的淋巴细胞中观察到PTA，其中大多数为T细胞，因此PTA与T淋巴细胞之间似乎存在关联。有可能PTA识别出在IM中扩增的特定T淋巴细胞亚群。或者，PTA可能是淋巴细胞中的一种短暂现象，仅出现在细胞的某些生物学状态下，如T淋巴细胞活化期间。
