Kurppa K, Holmberg P C, Kuosma E, Aro T, Saxén L
Department of Epidemiology and Biostatistics, University of Helsinki, Finland.
Teratology. 1991 Jul;44(1):51-5. doi: 10.1002/tera.1420440109.
To study the risk of anencephaly related to common cold during pregnancy, a case-control study was made. The series comprised 393 Finnish mothers of anencephalic children and their time-area-matched controls in the period 1964 through 1982. Seventy mothers of anencephalic infants and 17 controls had reported common cold in the first trimester [adjusted odds ratio 4.5; 95% confidence interval (2.2-9.1)]. Reported common cold in the second trimester was not associated with anencephaly. As suggested by our previous cohort study in the same population, a true viral influenza resembling "common cold" might not explain the observed association.
为研究孕期患普通感冒与无脑儿风险之间的关系，开展了一项病例对照研究。该研究纳入了1964年至1982年期间393名芬兰无脑儿母亲及其时间-区域匹配的对照。70名无脑儿婴儿的母亲和17名对照报告在孕早期患过普通感冒[调整优势比4.5；95%置信区间（2.2 - 9.1）]。孕中期报告患普通感冒与无脑儿无关联。正如我们之前在同一人群中进行的队列研究所表明的，类似“普通感冒”的真正病毒性流感可能无法解释所观察到的关联。
