Pal Amitava, Roy Debobroto, Adhikary Sudhir, Roy Anita, Dasgupta Mandira, Mandal Asok Kumar
Department of Gynecology and Obstetrics, Burdwan Medical College, Burdwan, India.
J Obstet Gynaecol India. 2012 Jun;62(3):312-6. doi: 10.1007/s13224-012-0223-z. Epub 2012 Aug 1.
To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women.
A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia.
Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p < 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group.
Preeclamptic women excrete less calcium than normotensive women. This parameter would predict preeclampsia earlier in pregnancy.
评估尿钙作为预测子痫前期诊断试验的有效性，并确定子痫前期和血压正常女性尿钙排泄的变化。
对60名年龄在20 - 30岁的初产妇进行前瞻性研究，所有产妇均在妊娠16周时入组，进行4周的临床随访，并测定24小时尿钙和肌酐。10名母亲发生子痫前期（研究组），50名母亲血压正常（对照组）。通过受试者工作特征曲线，选择24小时尿钙的截断水平来预测子痫前期。
在妊娠40周时，子痫前期女性的24小时尿总钙排泄量（87.0 ± 3.59 mg/24 h）明显低于血压正常女性（303.68 ± 17.699 mg/24 h）（p < 0.0001）。与血压正常组相比，研究组尿钙和钙/肌酐（Ca:Cr）比值从28周逐渐降低至40周。
子痫前期女性的钙排泄量低于血压正常女性。该参数可在妊娠早期预测子痫前期。
