Sanchez-Ramos L, Sandroni S, Andres F J, Kaunitz A M
Department of Obstetrics and Gynecology, University of Florida Health Science Center, Jacksonville, Florida.
Obstet Gynecol. 1991 Apr;77(4):510-3.
Recent studies have suggested that preeclampsia is associated with hypocalciuria. We compared 24-hour urine data from 143 obstetric patients: 33 with preeclampsia, 58 normotensives, and 52 patients with gestational hypertension. The mean maternal age, race, and parity of these three groups did not differ significantly. The patients with preeclampsia had significantly less excretion of total calcium (129.7 +/- 18.7 mg/24 hours) (mean +/- SEM) than normotensives (283.9 +/- 12.3) or those with gestational hypertension (233.2 +/- 22.3) (P = .0001). The mean arterial pressure and excretion of total protein were significantly increased in the preeclampsia group (P = .0001). Using the receiver operator curve, a urine calcium threshold of 12 mg/dL was chosen as predictive for the development of preeclampsia, with a sensitivity of 85%, specificity of 91%, and positive and negative predictive values of 85 and 91%, respectively. Urinary calcium levels below 12 mg/dL may help distinguish preeclampsia from other hypertensive disorders of pregnancy.
近期研究表明，子痫前期与尿钙减少有关。我们比较了143例产科患者的24小时尿液数据：33例子痫前期患者、58例血压正常者和52例妊娠期高血压患者。这三组患者的平均产妇年龄、种族和产次无显著差异。子痫前期患者的总钙排泄量（129.7±18.7毫克/24小时）（平均值±标准误）明显低于血压正常者（283.9±12.3）或妊娠期高血压患者（233.2±22.3）（P = 0.0001）。子痫前期组的平均动脉压和总蛋白排泄量显著升高（P = 0.0001）。使用受试者工作特征曲线，选择12毫克/分升的尿钙阈值作为子痫前期发生的预测指标，其敏感性为85%，特异性为91%，阳性预测值和阴性预测值分别为85%和91%。尿钙水平低于12毫克/分升可能有助于将子痫前期与其他妊娠高血压疾病区分开来。
