Espada Jesús, Calvo Moisés B, Díaz-Prado Silvia, Medina Vanessa
Biomedical Research Institute Alberto Sols (CSIC-UAM), Madrid, Spain.
Clin Transl Oncol. 2009 Jul;11(7):411-27. doi: 10.1007/s12094-009-0380-4.
Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefl y reviewed.
由分泌型Wnt蛋白介导的细胞内信号传导对于胚胎发育过程中细胞命运的建立和组织模式的正常形成，以及成体组织中组织稳态和干细胞功能的调节至关重要。Wnt信号通路的异常激活与不同肿瘤的发生直接相关。在此，将简要综述Wnt信号转导所涉及的组成成分和分子机制，以及支持该信号通路在干细胞功能调节和肿瘤发生中起核心作用的重要研究结果。
