Ma Y, Han G Q, Li C L, Cheng J R, Arison B H, Hwang S B
School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao. 1991;26(5):345-50.
Piper polysyphorum C.DC (Piperaceae) is indigenous to the southern part of China. In the course of screening for inhibitors of platelet activating factor (PAF), the nonpolar fraction was found to exhibit PAF inhibitory activity. One new neclignan named polysyphorin and three new enantiomeric forms of (+)-virolongin, (+)-grandisin and (+)-lancifolin D were isolated. Two known neolignans, wallichinine and hancinone D were also obtained from the same sources. The structure determination was based upon spectroscopic analysis (UV, IR, CD, MS, 1HNMR, 13CNMR, COSY) and derivative preparation. The structure for polysyphorin was established as threo-delta 7'-7-hydroxy-3,4,5,3',5'-pentamethoxy-8-O-4' -neolignan. It is a racemic enantiomer. The PAF inhibitory activities were reported.
多脉胡椒（Piper polysyphorum C.DC，胡椒科）原产于中国南部。在筛选血小板活化因子（PAF）抑制剂的过程中，发现其非极性部分具有PAF抑制活性。从中分离出一种新的木脂素类化合物多脉胡椒素（polysyphorin）以及（+）-维罗龙因（+）-virolongin、（+）-格兰迪辛（+）-grandisin和（+）-披针叶木兰脂素D（+）-lancifolin D的三种新对映体形式。还从相同来源获得了两种已知的新木脂素，瓦氏胡椒宁（wallichinine）和汉克酮D（hancinone D）。结构鉴定基于光谱分析（紫外、红外、圆二色、质谱、一维氢核磁共振、一维碳核磁共振、化学位移相关谱）和衍生物制备。多脉胡椒素的结构确定为苏式-δ7'-7-羟基-3,4,5,3',5'-五甲氧基-8-O-4'-新木脂素。它是一种外消旋对映体。报道了其PAF抑制活性。
