Aoshima Hisae, Kokubo Ken, Shirakawa Shogo, Ito Masayuki, Yamana Shuichi, Oshima Takumi
Vitamin C60 BioResearch Corporation, Tatsunuma Tatemono Bldg., 9F, 1-3-19, Yaesu, Chuo-ku, Tokyo 103-0028, Japan.
Biocontrol Sci. 2009 Jun;14(2):69-72. doi: 10.4265/bio.14.69.
The antimicrobial activities of fullerene C60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C60, gamma-cyclodextrin (gamma-CD)/C60, and nano-C60) and 3 types of fullerenols (C60(OH)12, C60(OH)36.8H2O, and C60(OH)44.8H2O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint of future application to cosmetics. Although pristine C60 demonstrated no antimicrobial activity, fullerenols exhibited good antimicrobial activity against Propionibacterium acnes, Staphylococcus epidermidis, Candida albicans, and Malassezia furfur. In particular, C60(OH)44 exhibited a strong and wide-ranging antimicrobial activity comparable to that of catechin. This compound exhibits antimicrobial activity via inhibition of microbial cell growth and not via bactericidal activity.
评估了富勒烯C60及其衍生物对6种细菌和2种真菌的抗菌活性。测试样品为水溶性富勒烯（聚乙烯吡咯烷酮（PVP）/C60、γ-环糊精（γ-CD）/C60和纳米C60）以及3种富勒醇（C60(OH)12、C60(OH)36·8H2O和C60(OH)44·8H2O）。从未来在化妆品中的应用角度，将它们的活性与（+）-儿茶素和扁柏酚的活性进行了比较。尽管原始的C60没有抗菌活性，但富勒醇对痤疮丙酸杆菌、表皮葡萄球菌、白色念珠菌和糠秕马拉色菌表现出良好的抗菌活性。特别是，C60(OH)44表现出与儿茶素相当的强大且广泛的抗菌活性。该化合物通过抑制微生物细胞生长而非杀菌活性来展现抗菌活性。
